Abstract: Talents are the basis of building a national scientific and technological innovation system. Technological personnel serving enterprises are not only the inevitable requirement of promoting mass entrepreneurship and innovation, but also help to stimulate the innovative spirit and motivation of technological personnel, and help to realize their own innovative significance and sense of innovation. This paper put forward the long-term mechanism of technological personnel serving enterprises from the aspects of orientation, selection, incentive, distribution, training and assessment, also put forward some countermeasures and suggestions on strengthening organization and implementation, exerting the guidance function of government, strengthening university support, strengthening cooperation and innovation, strengthening intermediary service, perfecting service system, strengthening technology market and adjusting allocation effectively.