Abstract: A method based on QuEChERS combined with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was established for the determination of fenarimol residues in loquat. The samples were extracted by acetonitrile, purified by N-primary secondary amine (PSA), and determined by high performance liquid chromatography-tandem mass spectrometry. The results showed that:the linearity of fenarimol was good in the concentration range of 0.5~200 μg·L^-1 (r²=0.999 4), the limit of detection was 0.14 μg·kg^-1, and the limit of quantitation was 0.5 μg·kg^-1. The average recovery rates of fenarimol were respectively 87.0%, 97.4% and 96.7% at the adding level of 2, 20 and 200 μg·kg^-1, with the relative standard deviations (RSD) of 8.3%, 7.9% and 4.3%, respectively. The method was simple, rapid and sensitive, which could meet the requirements of residue detection.