Abstract: In order to explore the regulatory effect of the active endophytic bacteria BF3252 in fig fruits on wheat under the drought (PEG-6000) stress, the wheat Jimai No.22 was used as the experimental material and cultured by using the hydroponic method. When the plant height of wheat seedling reached 10 cm, PEG-6000 (polyethylene glycol) was added to simulate the drought stress cultivation. During the process of stress cultivation, the active endophytic bacteria BF3252 of fig fruits was inoculated. By measuring the contents of soluble sugar (SS), proline (Pro), soluble protein (SP) and malondialdehyde (MDA) in wheat leaves, the effects of the active endophytic bacteria BF3252 in fig fruits on the physiological characteristics of wheat seedlings under the drought stress were analyzed. The results showed that under the conditions of drought stress PEG-6000(20%, 30%), the contents of SS, SP and Pro in wheat leaves increased to a certain extent, while the content of MDA decreased after the inoculation with the active endophytic bacteria BF3252 in fig fruits, indicating that the active endophytic bacteria BF3252 had a certain alleviating effect on the growth of wheat seedlings under the drought stress.