Abstract: In order to explore the suitable planting mode and single-seed precision sowing density of peanut, Quanhua No.22 was selected as the experimental material, and the split-plot design was adopted. The two planting methods of bare land and film mulching were the main treatments, and the five densities of single-seed sowing were the secondary treatments. The difference of plant growth and pod yield under two planting patterns with different seeding densities was compared with the double-seed conventional seeding density as comparison. The results showed that compared with the planting treatment of bare land, the planting treatment of film mulching could shorten the growth period and increase the yield, and the yield difference between them was extremely significant. The yields of peanut under the treatment of single-seed sowing density with the planting spacing of 17 cm×17 cm were all the highest in the secondary treatments of the two main treatments. The yield was 3 308.85 kg·hm^-2 under the treatment of bare land, which was 13.30% higher than that of the control group, and the difference was significant. The yield was 3 737.63 kg·hm^-2 under the treatment of film mulching, which was 8.34% higher than that of the control group, and the difference was extremely significant. The peanut variety Quanhua No.22 selected in the experiment was planted with the treatment of single-seed sowing and film mulching with the planting spacing of 17 cm×17 cm, which had good potential for increasing the yield and efficiency.