Abstract: The maize sheath rot is an important sheath disease in the production of maize. In order to screen the effective pesticide types and reasonably prevent the disease occurrence, the distribution of the maize sheath rot disease on the functional niche leaves of plant was investigated under the condition of natural infection in the field. Then, the effects of 11 kinds of fungicides on the control of maize sheath rot disease in the field and their effects on the yield of maize were studied. The results showed that under the condition of natural infection in the field, the maize sheath rot was more serious affected from the first leaf above ear to the second leaf below ear of maize plants. The field control efficiency of 25% pyraclostrobin EC,17% azoalkyl ether·epoxiceonazole SC,12.5% epoxiconazole SC,430 g·L^-1 tebuconazole EC,10% difenoconazole WP,400 g·L^-1 flusilaxole EC,50% fluazinam WP,40% azoalkyl ether·tebuconazole SC and 50% prochloraz-manganese WP to this disease was 78.59%, 71.901%, 70.59%, 62.03%, 60.96%, 59.09%, 58.82%, 51.60% and 41.6, respectively. Compared with that of the blank control, the increasing rates of maize yield under different treatments were 13.83%, 20.61%, 17.93%, 4.87%, 17.67%, 16.62%, 35.98%, 20.49% and 19.85%, respectively. epoxiconazole and flusilazole with the increased application of ethylicin had no obvious synergistic effect on the disease control, but had certain effect on increasing the maize yield. In conclusion, 25% pyraclostrobin EC, 17% azoalkyl ether·epoxiconazole SC and 12.5% epoxiconazole SC could effectively control the occurrence of maize sheath rot in the field, and save the loss of maize yield to different extents, which could be used as a reference agent for controlling the disease.