Abstract: By taking Jinxiu yellow peach as the research object, five treatments of the compounding application of fertilizers (represented by T1, T2, T3, T4, T5) were set up, and the conventional application of chemical fertilizer was used as the control group (CK) to explore the effects of different mixed application of organic fertilizers and chemical fertilizers on the growth, fruit quality and yield of yellow peach. The results showed that: the mixed application of organic fertilizer and chemical fertilizer could increase the content of soil organic matter in the orchard of yellow peach, and had significant effects on the contents of soil alkaline hydrolysis nitrogen, available phosphorus and rapidly available potassium. The rational mixed application of organic fertilizer and chemical fertilizer could promote the growth of yellow peach, increase the length of new shoots, and effectively improve the fruit quality of yellow peach. The content of soluble solids under the T3 and T4 treatments increased by 20.58% and 23.05%, respectively, compared with that of CK; the content of vitamin C increased by 20.19% and 18.65%, respectively, compared with that of CK; the average single fruit weight increased by 11.75% and 15.25%, respectively, compared with that of CK, and the yield increased by 13.38% and 12.43%, respectively, compared with that of CK. There was no significant difference in the single fruit weight and yield between T1 and T2 treatments, but they were significantly higher than those treated with CK and T5. The results showed that T3 and T4 treatments had the best effects. The recommended scheme in the production was as follows: the fertilizer for germination and the fertilizer for vary enlargement used the conventional application amount (that is, the fertilizer for germination was 0.25 kg·plant^-1, and the fertilizer for vary enlargement was 0.3 kg·plant^-1), while the application amount of basal fertilizer was the organic fertilizer of 20 kg·plant^-1+compound fertilizer of 1.00 kg·plant^-1 or the organic fertilizer of 25 kg·plant^-1+compound fertilizer of 0.75 kg·plant^-1.