Abstract: In order to clarify the occurrence of Solenopsis invicta in Quanzhou area and screen out the effective prevention and control agents suitable for the local Solenopsis invicta, the field control effects of 1% thiamethoxam amine granules, 1.8% abamectin cream, 0.05% indoxacarb bait and 5% rotenone soluble concentrate on the red fire ants were determined by investigating the habitat environment, living habits and transmission routes of the local Solenopsis invicta, in order to screen the best prevention and control agents. The results showed that the Solenopsis invicta in Quanzhou area were mainly distributed in the grassland (lawn), nursery, park, farmland, orchard and green belt, of which the suitable active temperature was 19−32℃. And they had mixed feeding distance habits, strong adaptability and various modes of spreading and diffusion. The field pharmacodynamic test showed that 1% thiamethoxam amine granules and 0.05% indoxacarb bait had good quick-acting property and durable effect on the active ant nests and active ergates. Although the 5% rotenone soluble concentrate had slightly slow quick-acting property, it had good persistence, while the quick-acting property and durable effect of 1.8% abamectin cream were both poor. Therefore, 1% thiamethoxam amine granules, 0.05% indoxacarb bait and 5% rotenone soluble concentrate were suitable for being promoted and applicated in the field. The results of this study could provide technical support and scientific basis for formulating the targeted prevention and control measures.