Abstract: Sthenoteuthis oualaniensis, an important marine resource, often contains high levels of endogenous formaldehyde in its untreated samples. To effectively reduce formaldehyde content, an orthogonal experiment was designed to optimize the application conditions, specifically examining the effects of soaking pH, soaking temperature, soaking time, and scavenger concentration. The results indicated that the optimal conditions were a soaking pH of 9.0, a soaking temperature of 80℃, a soaking time of 90 minutes, and the use of a formaldehyde scavenger containing 0.02% tea polyphenols and 0.1% cysteine. Under these treatment conditions, no residual formaldehyde was detected in the processed Sthenoteuthis oualaniensis products.