Abstract: In order to optimize the cultivation techniques of Sarcandra glabra and explore new medicinal parts to replace the traditional way of using the whole plant as medicine, the wild and cultivated Sarcandra glabra in different towns of Mingxi County, Fujian Province were selected. By analyzing the content of its pharmacodynamic components, the differences in the content of pharmacodynamic components among various parts were compared, and the correlation between the pharmacodynamic components and the physicochemical properties of the soil was further explored. The results showed that the contents of isofraxidin and rosmarinic acid in the whole plant of Sarcandra glabra from different towns of Mingxi County far exceeded the standard limits specified in the 2020 edition of the Chinese Pharmacopoeia. In particular, the content of rosmarinic acid was 10 times more than the standard limit of the Pharmacopoeia. Among different townships, the content of isofraxidin in Sarcandra glabra from Fengxi Township (wild) was the highest, reaching 0.110%, while the content of rosmarinic acid in Sarcandra glabra from Fengxi Township (cultivated) was the highest, reaching 0.253%, both of which were significantly higher than those in the samples from other townships. For Sarcandra glabra, isofraxidin was mainly concentrated in the roots, and the content order was root＞stem＞leaf; rosmarinic acid was mainly concentrated in the stems, and the content order was stem＞root＞leaf. Through the correlation analysis between the content of medicinal components in Sarcandra glabra and the physicochemical properties of the soil, it was found that the content of isofraxidin was extremely significantly positively correlated with the soil organic matter content and significantly positively correlated with the soil potassium content. The content of rosmarinic acid was extremely significantly positively correlated with the soil organic matter content. In summary, the research results were of great significance for guiding the planting and cultivation management of Sarcandra glabra. By adjusting the physicochemical properties such as soil organic matter and potassium content, the content of medicinal components in Sarcandra glabra could be improved, and the ideal township suitable for the growth of Sarcandra glabra in Mingxi County could be screened.