Abstract: To investigate the hypolipidemic effects of lotus leaf extract on high-fat-fed mice, the experiment divided the mice into a blank control group, a model group, and dose groups（including low-dose, medium-dose, and high-dose groups）. The model group and all dose groups were fed a high-fat diet to establish a hyperlipidemia model. After six weeks of continuous intervention, the body weight, organ indices, and blood lipid levels of the mice were recorded. The results showed that lotus leaf extract significantly inhibited food intake and body weight in mice（P ＜ 0.05）, with more pronounced weight reduction effects as the dosage increased. While no significant changes were observed in the thymus index, kidney index, or spleen index across all dose groups, the Lee's index, liver index, and epididymal fat index exhibited a trend toward normalization. Lotus leaf extract effectively alleviated obesity and metabolic burden induced by a high-fat diet in mice. In terms of blood lipid regulation, lotus leaf extract significantly reduced serum total cholesterol（TC）, triglycerides（TG）, and low-density lipoprotein（LDL）levels while increasing high-density lipoprotein（HDL）levels（P ＜ 0.05）. Overall, the findings indicate that a certain dosage of lotus leaf extract can effectively regulate blood lipid metabolism disorders induced by a high-fat diet in mice, providing a theoretical basis for the development of functional foods or pharmaceuticals.