Abstract: To establish a method for the rapid determination of 10 kinds of antiviral drug residues in pork based on QuEChERS-ultra high performance liquid chromatography tandem mass spectrometry（UPLC-MS/MS）. The samples were extracted by 1% acetic acid-acetonitrile, cleaned-up by QuEChERS, and then detected in positive ion multiple reaction monitoring（MRM）mode. The results showed that the 10 kinds of antiviral drugs showed good linearity（correlation coefficient r ＞0.9989）in the range of 2.5−125.0 μg·kg⁻¹; the limits of detection（LOD, S/N=3）and limits of quantification（LOQ, S/N=10）were in the ranges of 0.05−0.50 μg·kg⁻¹, 0.10−1.00 μg·kg⁻¹. The spiked experiments were carried out in blank samples at three levels（2.5, 5.0 and 20 μg·kg⁻¹, respectively）. The average recoveries ranged from 71.2% to 115.6% with relative standard deviations（RSDs）of 0.4%−8.3%. The method has high accuracy and sensitivity, and can meet the detection needs of antiviral drug residues in pork.