Abstract: The application of organic fertilizer in flue-cured tobacco production is a key technical measure to improve the yield and quality of tobacco leaves. In order to comprehensively understand the research status in this field, the research progress on the effects of organic fertilizer application on tobacco-planting soil improvement, flue-cured tobacco growth and development, yield and output value, chemical component harmony, and sensory smoking quality was systematically reviewed. On this basis, the regulatory mechanisms of the factors such as organic fertilizer type, application rate, ecological conditions, and flue-cured tobacco varieties on the application effects were deeply analyzed, and the research, development, and application trends of new functional organic fertilizers, including bio-organic fertilizers and biochar-based organic fertilizers were summarized. The future efforts should focus on screening the regionalized fertilization models, developing new functional organic fertilizers, and conducting the long-term positioning experiments, thus to provide a theoretical basis for the precision fertilization and sustainable development in tobacco leaf production.