Abstract: The application of organic fertilizer in flue-cured tobacco production is a key technical measure to enhance tobacco leaf yield and quality. To comprehensively understand the research status in this field, this paper systematically reviews the research progress on the effects of organic fertilizer application on tobacco-planting soil improvement, flue-cured tobacco growth and development, yield and output value, chemical component harmony, and sensory smoking quality. On this basis, it deeply analyzes the regulatory mechanisms of factors such as organic fertilizer type, application rate, ecological conditions, and flue-cured tobacco varieties on the application effects, and summarizes the research, development, and application trends of new functional organic fertilizers, including bio-organic fertilizers and biochar-based organic fertilizers. Future efforts should focus on screening regionalized fertilization models, developing new functional organic fertilizers, and conducting long-term positioning experiments, to provide a theoretical basis for precision fertilization and sustainable development in tobacco leaf production.