Abstract: In order to screen out the effective fungicides and optimal application methods for controlling anthracnose and leaf spot in Polygonatum cyrtonema grown in eastern Fujian, five commonly used fungicides were selected to carry out the field efficacy trials. Then, the differences in the control effects of methyl thiophanate and prochloraz were compared between early preventive application in the early stage of disease occurrence and therapeutic application in the late stage of disease occurrence. The fungicide screening results showed that all the five tested fungicides exhibited control effects against both diseases. Among them, prochloraz 450 g·L⁻¹ EW demonstrated the best efficacy, achieving over 90% preventing effect against both anthracnose and leaf spot. Methyl thiophanate 70% WP showed lower efficacy, with the control rates of 51.37% and 47.04%, respectively. Regarding the application methods, early preventive application was significantly more effective than late therapeutic application. Notably, the early preventive treatment of prochloraz 450 g·L⁻¹ EW achieved the control rates of 82.48% for anthracnose and 77.23% for leaf spot, which were superior to its therapeutic application treatment. In summary, prochloraz was the preferred fungicide for anthracnose and leaf spot of Polygonatum cyrtonema, and the early prevention at the initial stage of disease development was the best application strategy, which could be popularized and applied in production.