Abstract: Symptom of sturgeon ascites syndrome and diagnosis methods were introduced in this paper, and determining that pathogenic bacteria was Aeromonas hydrophila. The comprehensive control technique was proved to prevent at the early and middle stages, and to cure at the late stage based on scientific raising practice. Six drugs, Florfenicol, vitamin C, Vitamin E, Guogensu, Qihuangsu and Jinmeikang, could be used for curing ascites syndrome.