Abstract: Plot experiment and large-scale demonstration test of 52.5% Equation-pro on controlling grape downy mildew were conducted, and the results showed that 52.5% Equation-pro water dispersible granule presented effective control efficacy on grape downy mildew. In the plot experiment, the efficacy of 1800 times, and 2000 times solution of Equation-pro were respectively 11.9 and 7.0 percentage points higher than that of 1500 times solution of 72% Cymoxanil·Mancozeb after 7 days of the first application, and 17.4 and 14.1 percentage points higher than that of the control after 7 days of the second application. In the large-scale demonstration test, it was effective on controlling grape downy mildew at the initial stage by using 2000 times solution of 52.5% Equation-pro in every 5 days for continuous two times.