Abstract: Years demonstration and planting proved that the hybrid bitter gourd variety ‘Qiansheng 105’ was with high yield and high quality, strong resistance, credible appearance, and good commodity with prefect appearance. In this paper, the high-yield cultivation technique for ‘Qisheng 105’ was summarized, including seedling cultivation, land preparation and fertilization, field planting and management, pests and diseases control, harvesting, and so on.