Abstract: In order to clarify the effect of corn straw+sugarcane leaf tip+cassava residue compound feed on the growth and economic benefits of fattening beef cattle, the fresh sweet corn straw (control group, CK), test group Ⅰ (fresh corn straw:fresh sugarcane leaf tip:fresh cassava residue was 3:1:1), test group Ⅱ (fresh corn straw:fresh sugarcane leaf tip:fresh cassava residue was 2:2:1), test group Ⅲ (fresh corn straw:fresh sugarcane leaf tip:fresh cassava residue was 1:3:1), test group Ⅳ (dry corn straw:dry sugarcane leaf tip:dry cassava residue was 3:1:1), test group Ⅴ (dry corn straw:dry sugarcane leaf tip:dry cassava residue was 2:2:1), test group Ⅵ (dry corn straw:dry sugarcane leaf tip:dry cassava residue was 1:3:1) were respectively set up to carry out the feeding experiment. The results showed that the order of fattening effect of beef cattle was control group (CK) > test group I > test group Ⅳ > test group Ⅱ > test group Ⅴ > test group Ⅲ > test group Ⅵ, while the order of gross profit was test group Ⅳ > test group Ⅱ > test group Ⅴ > test group Ⅰ > control group (CK) > test group III > test group Ⅵ. The comprehensive fattening effect and economic benefit were obtained in test group Ⅳ (dry corn straw:dry sugarcane leaf tip:dry cassava residue was 3:1:1). The average daily gain was 858.97 kg per head, and the gross profit was 4 839.12 yuan per head, which was significantly increased by 10.83% compared with the control group (CK).