Abstract: The contents of various veterinary drug residues in fresh aquatic products sold in Eastern Fujian were monitored, so as to understand the pollution status of veterinary drug residues in the fresh aquatic products in this region. By means of random sampling, 495 samples of fresh aquatic products were collected from Eastern Fujian including the municipal district of Ningde City, Fu'an, Xiapu, Zhouning, Zherong and Gutian in 2019, and the contents of various veterinary drug residues such as enrofloxacin, ofloxacin and nitrofuran metabolites in the samples were detected by LC-MS/MS after pretreatment. The results showed that many kinds of veterinary drug residues were detected at different levels in the fresh aquatic products sold in Eastern Fujian. Among the collected 495 samples, 121 batches of veterinary drug residues were detected, and the detectable rate was 24.44% (121/495). Among them, there were 15 batches of unqualified products, and the fraction defective was 3.03% (15/495). The unqualified products involved 3 batches of unqualified enrofloxacin, 10 batches of unqualified ofloxacin and 2 batches of unqualified nitrofuran metabolites. The various degrees of contamination of veterinary drug residues in the fresh aquatic products sold in Eastern Fujian indicated that there was a certain degree of veterinary drug abuse in the aquaculture in this region, and the results also showed that the usage frequency of veterinary drug in the aquaculture of fish and bullfrog was higher than that of shrimps, crabs and other aquatic products.