Abstract: In order to establish a method for the determination of 5 kinds of pesticide residues in strawberries by QuEChERS-gas chromatography, the acetonitrile was used to extract the pesticide from strawberries, and the appropriate amount of ethylenediamine-n-propylsilane (PSA), anhydrous magnesium sulfate, and graphitized carbon black (GCB) were selected for the dispersive solid-phase extraction. GC-ECD detection was conducted on the filtering membrane of the purification solution. The orthogonal test design and variance analysis were conducted by using the software of SPSS statistics version 19. The results showed that the optimal purification combination was A3B3C2, that was, ethylamine-n-propylsilane (PSA) 125 mg, graphite carbon black (GCB) 50 mg, and anhydrous magnesium sulfate 250 mg, and the recoveries of procymidone, prochloraz, chlorothalonil, chlorpyrifos and cyfluthrin were 96.5%, 94.8%, 97.6%, 99.1% and 97.9%, respectively. The method was suitable for the detection of 5 kinds of pesticide residues such as procymidone in strawberries by optimizing the combination of purification agent measured by QuEChERS-gas chromatography.