Abstract: In this study, in order to find out whether organic-inorganic compound fertilizer could be used in the growth period of citrus fruit trees,organic-inorganic compound fertilizer was prepared based on the characteristics of fertilizer requirement during the fruit expansion of Tangelo in Jianyang, and 4 kinds of fertilizing amount were conducted to discuss to the effects of different level of organic-inorganic compound fertilizer on the yield and quality of Tangelo in Jianyang. The results showed that the application of organic-inorganic compound fertilizer during the fruit expansion of Tangelo had no significant effect on the yield of Tangelo in Jianyang, reduced the peel thickness and the content of soluble acid, increased the content of soluble sugar, the content of ascorbic acid and the sugar-acid ratio. Meanwhile, the relationship between the application amount of organic-inorganic compound fertilizer and the reducing sugar, ascorbic acid, soluble sugar, and suga-acid ratio conformed to the cubic regression equation. The optimal fertilization application was suggested to be 5.56-8.30 kg per plant according to the results of the cubic regression equation and the comprehensive performance of the quality characters of Tangelo in Jianyang.