Abstract: In order to explore the effects of different organic fertilizers on the agronomic traits and economic benefits of Pseudostellaria heterophylla, the mountainous areas and paddy fields with different soil conditions were selected as the experimental areas, and the differences in plant height and yield after planting Pseudostellaria heterophylla with three kinds of organic fertilizers as the base fertilizers were compared. Then, the economic benefits were also analyzed in combination with the cost. The results showed that: The treatments of Jiangping, Zhongnong and Zhonghua organic fertilizer could significantly promote the plant height and yield of Pseudostellaria heterophylla planted in the mountainous areas (P<0.05), which were increased by 163.02%, 189.96% and 122.70% respectively compared with the control Shima compound fertilizer. However, the plant height and yield of Pseudostellaria heterophylla planted in the paddy field were not significantly promoted (P>0.05), which were increased by 19.13%, 7.52% and 24.37% respectively compared with the control Shima compound fertilizer. The experiment showed that the three kinds of organic fertilizers tested were more suitable for the improvement of mountain soil. According to the ratio of increasing output value to fertilizer input, the cost of Zhongnong organic fertilizer to improve the mountainous area was the lowest, while the cost of Zhonghua organic fertilizer to improve the paddy field was the lowest.